PUBLICATIONS AND PRESENTATIONS
Spicer, J, McGrath, L. et al (2022). Platform study of neoadjuvant durvalumab (D) alone or combined with novel agents in patients (pts) with resectable, early-stage non-small cell lung cancer (NSCLC): Pharmacodynamic correlates and circulating tumor DNA (ctDNA) dynamics in the NeoCOAST study. Mini-Oral Presentation at ESMO Congress.
Yap, T, McGrath, L. et al (2022). First in Human Phase 1/2 ICONIC Trial of the ICOS agonist vopratelimab alone and with nivolumab: ICOS high CD4 T cell populations and predictors of response. Clinical Cancer Research.
Cascone, T, McGrath L., et al. (2022). NeoCOAST: open-label, randomized, phase 2, multidrug platform study of neoadjuvant durvalumab alone or combined with novel agents in patients (pts) with resectable, early-stage non-small-cell lung cancer (NSCLC). Clinical trials plenary presentation at AACR Annual Meeting.
McGrath, L. et al. (2021). "Tumor associated macrophages and resistance to immune checkpoint blockade: consideration of cancer indications for the clinical development of JTX-8064, an anti-LILRB2/ILT4 monoclonal antibody". Virtual presentation at AACR Annual Meeting (Abstract #1727).
Dépis, F, McGrath, L, et al. (2020). "Preclinical evaluation of JTX-1811, an anti-CCR8 antibody with enhanced ADCC activity, for preferential depletion of tumor-infiltrating regulatory T cells." Virtual presentation at AACR Annual Meeting.
Hanson, A, McGrath, L, et al. (2020). "ICOS hi CD4 T cells emerging on vopratelimab treatment have Th1 central memory characteristics and may contribute to durability of clinical responses." Virtual presentation at AACR Annual Meeting.
Lim, E, McGrath, L, et al. (2020). "A phase I, open-label, multicenter study to assess the safety, pharmacokinetics and preliminary anti-tumor activity of AZD4635 both as monotherapy and in combination in patients with advanced solid malignancies: results from prostate cancer patients (NCT02740985)." Virtual presentation at ASCO Annual Meeting.
Yap, T, McGrath, L, et al. (2020). "Association of an RNA signature (RS) with emergence of ICOS hi CD4 T cells and efficacy outcomes for the ICOS agonist vopratelimab (vopra) and nivolumab (nivo) in patients (pts) on the ICONIC trial." Poster presentation at ASCO-SITC Clinical Immuno-Oncology Symposium, Orlando, FL.
Harvey C, McGrath L, et al. (2019). “Genetic and molecular profiling of ICOS hi CD4 T cells demonstrates clonal expansion of Th1 effector cells following JTX-2011 treatment in subjects with solid tumors”. Poster presentation at AACR Annual Meeting, Atlanta, GA.
Bendell J, McGrath L, et al. (2019). “Evidence of immune activation in the first-in-human Phase Ia dose escalation study of the adenosine 2a receptor antagonist, AZD4635, in patients with advanced solid tumors”. Poster presentation at AACR Annual Meeting, Atlanta, GA.
McGrath et al. (2018). “Intratumoral T cell receptor β repertoire sequencing identifies connections to expression of inhibitory checkpoints, HPV status, and smoking history”. Poster presentation at Keystone Symposia: T cell dysfunction, cancer and infection, Breckenridge, CO.
McGrath et al. (2018). “Intratumoral T cell receptor β repertoire as a biomarker in head and neck squamous cell carcinoma”. Cancer Immunology Research 6 (9S), B83-B83.
McGrath et al. (2018). “Capturing T cell receptor clones from circulating free DNA in cancer patients with solid malignancies”. Cancer Research 78 (13S), 4582-4582.
LL McGrath. (2018). “Boosting the immune system to fight cancer, and how genomics can help”. Invited talk at Rhode Island College, Providence, RI.
LL McGrath, TJ Lubinski, JC Barrett and H Gardner. (2017). “TCRbiter: Detecting T cell receptor rearrangements in silico from non-targeted DNA-sequencing (WGS/WES).”. biorxiv doi: https://doi.org/10.1101/201947
LL McGrath. (2016). “Profiling T cell repertoires from non-targeted DNA-sequencing (WGS/WES)”. Invited talk at Boston Pharma & pBRANE Annual Symposium, Cambridge, MA.
LL McGrath, S Vollmer, S Kaluziak, J Ayers. (2016). De novo transcriptome assembly for the lobster Homarus americanus and characterization of differential gene expression across nervous system tissues. BMC Genomics 17:63. DOI: 10.1186/s12864-016-2373-3 *Here is a recap for the lay audience
LL McGrath. (2015). Using RNA-seq to characterize localized expression of neuromodulators and their role in transcriptional regulation. Poster presented at Gordon Research Conference: Hong Kong, People’s Republic of China.
L Lewis, J Ayers. (2014). Temperature Preference and Acclimation in the Jonah Crab, Cancer borealis. Journal of Experimental Marine Biology and Ecology, 455, 7-13. *Here is a recap for the lay audience
L Lewis McGrath, C Braun, S Kaluziak, S Vollmer, J Ayers. Regulation of gene expression by the neuromodulator Proctolin. Program No. 828.20. Neuroscience 2014 Abstracts. Washington, DC: Society for Neuroscience, 2014. Online.
LL McGrath, J Morgan. (2014). The Nerve: Marine organisms provide insight into the human nervous system. Invited talk at NEOSEC Ocean Literacy Summit: Woods Hole, MA.
PATENTS/PATENT APPLICATIONS
Methods of Treating Cancer
LL Mcgrath, C Harvey, LAW Deborah, A Hanson
US Patent App. 17/286,104
Antibodies and fusion proteins that bind to ccr8 and uses thereof
LL Mcgrath, F Dépis, HU Changyun, LG Presta, JA Buggé
US Patent App. 17/171,866
PUBLISHED TOOLS
TCRbiter https://github.com/AstraZeneca-NGS/tcrbiter
Use: Calculate T cell infiltration, extract T cell clones from WGS/WXS data
PUBLISHED DATASETS
American lobster (Homarus americanus) transcriptome (raw data): NCBI BioProject Accession: PRJNA297570
Assembled and annotated transcriptome: http://dx.doi.org/10.5061/dryad.h617h
When using this data, please cite the original publication and data dryad package:
McGrath LL, Vollmer SV, Kaluziak ST, Ayers J (2016) De novo transcriptome assembly for the lobster Homarus americanus and characterization of differential gene expression across nervous system tissues. BMC Genomics 17: 63. http://dx.doi.org/10.1186/s12864-016-2373-3
McGrath LL, Vollmer SV, Kaluziak ST, Ayers J (2016) Data from: De novo transcriptome assembly for the lobster Homarus americanus and characterization of differential gene expression across nervous system tissues. Dryad Digital Repository. http://dx.doi.org/10.5061/dryad.h617h
Spicer, J, McGrath, L. et al (2022). Platform study of neoadjuvant durvalumab (D) alone or combined with novel agents in patients (pts) with resectable, early-stage non-small cell lung cancer (NSCLC): Pharmacodynamic correlates and circulating tumor DNA (ctDNA) dynamics in the NeoCOAST study. Mini-Oral Presentation at ESMO Congress.
Yap, T, McGrath, L. et al (2022). First in Human Phase 1/2 ICONIC Trial of the ICOS agonist vopratelimab alone and with nivolumab: ICOS high CD4 T cell populations and predictors of response. Clinical Cancer Research.
Cascone, T, McGrath L., et al. (2022). NeoCOAST: open-label, randomized, phase 2, multidrug platform study of neoadjuvant durvalumab alone or combined with novel agents in patients (pts) with resectable, early-stage non-small-cell lung cancer (NSCLC). Clinical trials plenary presentation at AACR Annual Meeting.
McGrath, L. et al. (2021). "Tumor associated macrophages and resistance to immune checkpoint blockade: consideration of cancer indications for the clinical development of JTX-8064, an anti-LILRB2/ILT4 monoclonal antibody". Virtual presentation at AACR Annual Meeting (Abstract #1727).
Dépis, F, McGrath, L, et al. (2020). "Preclinical evaluation of JTX-1811, an anti-CCR8 antibody with enhanced ADCC activity, for preferential depletion of tumor-infiltrating regulatory T cells." Virtual presentation at AACR Annual Meeting.
Hanson, A, McGrath, L, et al. (2020). "ICOS hi CD4 T cells emerging on vopratelimab treatment have Th1 central memory characteristics and may contribute to durability of clinical responses." Virtual presentation at AACR Annual Meeting.
Lim, E, McGrath, L, et al. (2020). "A phase I, open-label, multicenter study to assess the safety, pharmacokinetics and preliminary anti-tumor activity of AZD4635 both as monotherapy and in combination in patients with advanced solid malignancies: results from prostate cancer patients (NCT02740985)." Virtual presentation at ASCO Annual Meeting.
Yap, T, McGrath, L, et al. (2020). "Association of an RNA signature (RS) with emergence of ICOS hi CD4 T cells and efficacy outcomes for the ICOS agonist vopratelimab (vopra) and nivolumab (nivo) in patients (pts) on the ICONIC trial." Poster presentation at ASCO-SITC Clinical Immuno-Oncology Symposium, Orlando, FL.
Harvey C, McGrath L, et al. (2019). “Genetic and molecular profiling of ICOS hi CD4 T cells demonstrates clonal expansion of Th1 effector cells following JTX-2011 treatment in subjects with solid tumors”. Poster presentation at AACR Annual Meeting, Atlanta, GA.
Bendell J, McGrath L, et al. (2019). “Evidence of immune activation in the first-in-human Phase Ia dose escalation study of the adenosine 2a receptor antagonist, AZD4635, in patients with advanced solid tumors”. Poster presentation at AACR Annual Meeting, Atlanta, GA.
McGrath et al. (2018). “Intratumoral T cell receptor β repertoire sequencing identifies connections to expression of inhibitory checkpoints, HPV status, and smoking history”. Poster presentation at Keystone Symposia: T cell dysfunction, cancer and infection, Breckenridge, CO.
McGrath et al. (2018). “Intratumoral T cell receptor β repertoire as a biomarker in head and neck squamous cell carcinoma”. Cancer Immunology Research 6 (9S), B83-B83.
McGrath et al. (2018). “Capturing T cell receptor clones from circulating free DNA in cancer patients with solid malignancies”. Cancer Research 78 (13S), 4582-4582.
LL McGrath. (2018). “Boosting the immune system to fight cancer, and how genomics can help”. Invited talk at Rhode Island College, Providence, RI.
LL McGrath, TJ Lubinski, JC Barrett and H Gardner. (2017). “TCRbiter: Detecting T cell receptor rearrangements in silico from non-targeted DNA-sequencing (WGS/WES).”. biorxiv doi: https://doi.org/10.1101/201947
LL McGrath. (2016). “Profiling T cell repertoires from non-targeted DNA-sequencing (WGS/WES)”. Invited talk at Boston Pharma & pBRANE Annual Symposium, Cambridge, MA.
LL McGrath, S Vollmer, S Kaluziak, J Ayers. (2016). De novo transcriptome assembly for the lobster Homarus americanus and characterization of differential gene expression across nervous system tissues. BMC Genomics 17:63. DOI: 10.1186/s12864-016-2373-3 *Here is a recap for the lay audience
LL McGrath. (2015). Using RNA-seq to characterize localized expression of neuromodulators and their role in transcriptional regulation. Poster presented at Gordon Research Conference: Hong Kong, People’s Republic of China.
L Lewis, J Ayers. (2014). Temperature Preference and Acclimation in the Jonah Crab, Cancer borealis. Journal of Experimental Marine Biology and Ecology, 455, 7-13. *Here is a recap for the lay audience
L Lewis McGrath, C Braun, S Kaluziak, S Vollmer, J Ayers. Regulation of gene expression by the neuromodulator Proctolin. Program No. 828.20. Neuroscience 2014 Abstracts. Washington, DC: Society for Neuroscience, 2014. Online.
LL McGrath, J Morgan. (2014). The Nerve: Marine organisms provide insight into the human nervous system. Invited talk at NEOSEC Ocean Literacy Summit: Woods Hole, MA.
PATENTS/PATENT APPLICATIONS
Methods of Treating Cancer
LL Mcgrath, C Harvey, LAW Deborah, A Hanson
US Patent App. 17/286,104
Antibodies and fusion proteins that bind to ccr8 and uses thereof
LL Mcgrath, F Dépis, HU Changyun, LG Presta, JA Buggé
US Patent App. 17/171,866
PUBLISHED TOOLS
TCRbiter https://github.com/AstraZeneca-NGS/tcrbiter
Use: Calculate T cell infiltration, extract T cell clones from WGS/WXS data
PUBLISHED DATASETS
American lobster (Homarus americanus) transcriptome (raw data): NCBI BioProject Accession: PRJNA297570
Assembled and annotated transcriptome: http://dx.doi.org/10.5061/dryad.h617h
When using this data, please cite the original publication and data dryad package:
McGrath LL, Vollmer SV, Kaluziak ST, Ayers J (2016) De novo transcriptome assembly for the lobster Homarus americanus and characterization of differential gene expression across nervous system tissues. BMC Genomics 17: 63. http://dx.doi.org/10.1186/s12864-016-2373-3
McGrath LL, Vollmer SV, Kaluziak ST, Ayers J (2016) Data from: De novo transcriptome assembly for the lobster Homarus americanus and characterization of differential gene expression across nervous system tissues. Dryad Digital Repository. http://dx.doi.org/10.5061/dryad.h617h